INTERSTITIAL PERFUSION CULTURE WITH SPECIFIC SOLUBLE FACTORS INHIBITS TYPE I COLLAGEN PRODUCTION FROM HUMAN OSTEOARTHRITIC CHONDROCYTES IN CLINICAL-GRADE COLLAGEN SPONGES.

Articular cartilage has poor healing ability and cartilage injuries often evolve to osteoarthritis.Cell-based strategies aiming to engineer cartilaginous tissue through the combination of biocompatible scaffolds and articular chondrocytes represent an alternative to standard surgical techniques.In this context, perfusion bioreactors have been intro

The construction of prestressed concrete bridges has witnessed a steep increase for the past 50 years worldwide.The constructed bridges exposed to various environmental conditions deteriorate all along their service life.One such degradation is corrosion, which can cause significant damage if it occurs on the main structural components, such as pre

Coxiella burnetii is the etiological agent of the zoonotic disease Q fever, which is featured by its ability to replicate in acid vacuoles resembling the lysosomal network.One key virulence determinant of C.burnetii is the Dot/Icm system that transfers more than 150 effector proteins into host cells.These effectors function to construct the lysosom